Pathology — MCQs August 22, 2025 by u930973931_answers 50 Score: 0 Attempted: 0/50 Subscribe 1. What is the study of the causes of diseases called? (A) Etiology (B) Pathogenesis (C) Morphology (D) Epidemiology 2. Which pigment is responsible for jaundice? (A) Hemoglobin (B) Bilirubin (C) Melanin (D) Hemosiderin 3. Which type of necrosis is most commonly seen in tuberculosis? (A) Coagulative necrosis (B) Liquefactive necrosis (C) Caseous necrosis (D) Fat necrosis 4. Which cells are called “giant cells” in granulomas? (A) Epithelioid cells (B) Langhans giant cells (C) Plasma cells (D) Fibroblasts 5. Which type of inflammation is characterized by pus formation? (A) Fibrinous (B) Purulent (C) Serous (D) Granulomatous 6. What is the first white blood cell to arrive at the site of acute inflammation? (A) Lymphocyte (B) Monocyte (C) Neutrophil (D) Eosinophil 7. The deposition of calcium in normal tissue is called: (A) Dystrophic calcification (B) Metastatic calcification (C) Physiological calcification (D) None of these 8. Which type of necrosis is typical of myocardial infarction? (A) Coagulative necrosis (B) Liquefactive necrosis (C) Caseous necrosis (D) Fibrinoid necrosis 9. The tumor derived from glandular epithelium is called: (A) Squamous cell carcinoma (B) Adenocarcinoma (C) Sarcoma (D) Melanoma 10. Reed–Sternberg cells are characteristic of: (A) Non-Hodgkin lymphoma (B) Hodgkin lymphoma (C) Multiple myeloma (D) Leukemia 11. Which stain is used to demonstrate amyloid? (A) Hematoxylin and eosin (B) Congo red (C) PAS stain (D) Giemsa stain 12. Which is the most common malignant tumor in humans? (A) Sarcoma (B) Carcinoma (C) Lymphoma (D) Melanoma 13. Which type of cellular adaptation occurs in response to increased workload? (A) Atrophy (B) Hypertrophy (C) Hyperplasia (D) Metaplasia 14. Which of the following is an example of a tumor suppressor gene? (A) RAS (B) MYC (C) p53 (D) HER2 15. Which viral infection is associated with Burkitt lymphoma? (A) Hepatitis B virus (B) Epstein-Barr virus (C) Human papillomavirus (D) HIV 16. The replacement of one adult cell type by another is called: (A) Atrophy (B) Metaplasia (C) Dysplasia (D) Neoplasia 17. Which type of necrosis is seen in brain infarction? (A) Coagulative necrosis (B) Liquefactive necrosis (C) Fat necrosis (D) Caseous necrosis 18. Which is the most radiosensitive phase of the cell cycle? (A) G0 phase (B) G1 phase (C) S phase (D) M phase 19. Which immunoglobulin is deposited in Goodpasture’s syndrome? (A) IgA (B) IgM (C) IgE (D) IgG 20. Which type of necrosis is associated with acute pancreatitis? (A) Caseous necrosis (B) Fat necrosis (C) Fibrinoid necrosis (D) Coagulative necrosis 21. What is the most common cause of myocardial infarction? (A) Coronary artery spasm (B) Coronary artery thrombosis (C) Coronary embolism (D) Coronary artery dissection 22. Which is a benign tumor of smooth muscle? (A) Fibroma (B) Lipoma (C) Leiomyoma (D) Rhabdomyoma 23. Which cells are known as “sentinel cells” of inflammation? (A) Neutrophils (B) Dendritic cells (C) Eosinophils (D) Plasma cells 24. The presence of metastatic calcification is most commonly associated with: (A) Hypocalcemia (B) Hypercalcemia (C) Hyponatremia (D) Hyperkalemia 25. Which carcinoma is strongly linked to cigarette smoking? (A) Renal carcinoma (B) Lung carcinoma (C) Liver carcinoma (D) Pancreatic carcinoma 26. What is the term for a reversible change in cell size, shape, and organization? (A) Atrophy (B) Dysplasia (C) Metaplasia (D) Hypertrophy 27. The Philadelphia chromosome is associated with: (A) Acute lymphoblastic leukemia (B) Chronic myeloid leukemia (C) Multiple myeloma (D) Hodgkin lymphoma 28. Which tumor marker is elevated in hepatocellular carcinoma? (A) CEA (B) AFP (C) CA-125 (D) PSA 29. The presence of Russell bodies indicates: (A) Excess immunoglobulin synthesis (B) Excess collagen deposition (C) Amyloid deposition (D) Hemoglobin accumulation 30. Which of the following is an example of autosomal recessive disease? (A) Huntington’s disease (B) Sickle cell anemia (C) Marfan syndrome (D) Neurofibromatosis 31. Which disease is characterized by “onion-skin” appearance of arteries? (A) Hyaline arteriosclerosis (B) Hyperplastic arteriosclerosis (C) Atherosclerosis (D) Vasculitis 32. The most common site of metastasis in carcinoma is: (A) Lung (B) Liver (C) Lymph nodes (D) Bone 33. Which type of shock is caused by severe infection? (A) Cardiogenic shock (B) Hypovolemic shock (C) Septic shock (D) Anaphylactic shock 34. Which is the commonest primary malignant bone tumor? (A) Osteosarcoma (B) Chondrosarcoma (C) Ewing’s sarcoma (D) Fibrosarcoma 35. Which is the most common leukemia in adults? (A) ALL (B) AML (C) CLL (D) CML 36. Which condition shows “starry-sky” appearance on histology? (A) Hodgkin lymphoma (B) Burkitt lymphoma (C) Multiple myeloma (D) Leukemia 37. Which pigment accumulates in anthracosis? (A) Melanin (B) Lipofuscin (C) Carbon (D) Hemosiderin 38. Which infection is commonly associated with cervical carcinoma? (A) Hepatitis C virus (B) Epstein-Barr virus (C) Human papillomavirus (D) HIV 39. Which type of infarct occurs in solid organs with single blood supply? (A) White infarct (B) Red infarct (C) Hemorrhagic infarct (D) None of these 40. Which blood test is used to detect syphilis? (A) VDRL (B) Widal (C) ELISA (D) Coombs test 41. Which hereditary disease shows “Lysosomal storage disorder”? (A) Gaucher disease (B) Marfan syndrome (C) Huntington’s disease (D) Cystic fibrosis 42. Which tumor marker is used in monitoring prostate carcinoma? (A) CEA (B) PSA (C) AFP (D) CA-19.9 43. The most common cause of cirrhosis worldwide is: (A) Alcohol (B) Hepatitis B (C) Hepatitis C (D) Non-alcoholic fatty liver disease 44. Which is the most common malignant tumor in children? (A) Neuroblastoma (B) Wilms tumor (C) Retinoblastoma (D) ALL 45. Which bacteria is strongly linked to gastric carcinoma? (A) H. pylori (B) E. coli (C) Salmonella (D) Clostridium 46. Which type of necrosis is associated with immune reactions in blood vessels? (A) Caseous necrosis (B) Fat necrosis (C) Fibrinoid necrosis (D) Coagulative necrosis 47. Which condition is characterized by Auer rods? (A) Acute myeloid leukemia (B) Chronic lymphocytic leukemia (C) Hodgkin lymphoma (D) Multiple myeloma 48. Which tumor marker is elevated in colorectal carcinoma? (A) AFP (B) PSA (C) CEA (D) CA-125 49. Which condition is associated with Bence Jones proteins? (A) Hodgkin lymphoma (B) Multiple myeloma (C) Burkitt lymphoma (D) CML 50. Which type of necrosis is most common in bacterial abscesses? (A) Coagulative necrosis (B) Caseous necrosis (C) Liquefactive necrosis (D) Fat necrosis