| River Name | Length (km) | Major Features | Drainage Basin | Notable Locations |
| Oubangui River | 1,120 | Forms part of the border with the DRC; vital for transportation | Congo River Basin | Bangui, Zongo |
| Sangha River | 600 | Known for rich biodiversity; important for local fishing communities | Congo River Basin | Lobaye Region |
| Mambéré River | 400 | A tributary of the Oubangui; important for agriculture | Congo River Basin | Mambéré-Kadeï |
| Gribingui River | 200 | Flows into the Oubangui; subject to seasonal changes | Congo River Basin | Bouar |
| Lobaye River | 200 | Flows through rainforest areas; vital for local ecosystems | Congo River Basin | Lobaye Region |
| Mbomou River | 400 | Forms part of the border with South Sudan; important for local transport | Congo River Basin | Bangassou |
| Kotto River | 300 | Flows through the central region; important for local communities | Congo River Basin | Kotto, Ippy |
| Bimbo River | 150 | Flows near Bangui; essential for fishing and local irrigation | Congo River Basin | Bimbo, near Bangui |