| Name | Term Start | Term End | Notes |
| Barthélemy Boganda | 1960 | 1963 | First Prime Minister; focused on national unity. |
| David Dacko | 1963 | 1966 | Led during a period of instability. |
| Jean Bedel Bokassa | 1966 | 1976 | Took power in a coup; declared himself Emperor. |
| David Dacko | 1976 | 1979 | Returned after Bokassa’s regime. |
| Kolingba | 1979 | 1981 | Oversaw a transitional government. |
| André Kolingba | 1981 | 1993 | Established a multi-party system. |
| Ange-Félix Patassé | 1993 | 2001 | Focused on democratic governance and national reconciliation. |
| Martin Ziguélé | 2001 | 2003 | Ousted in a coup; faced significant unrest. |
| François Bozizé | 2003 | 2013 | Came to power through a coup; faced ongoing conflict. |
| Nicolas Tiangaye | 2013 | 2014 | Interim Prime Minister during a transitional period. |
| Catherine Samba-Panza | 2014 | 2016 | First female Prime Minister; worked on peace initiatives. |
| Faustin-Archange Touadéra | 2016 | Present | Elected to restore stability and promote reconciliation. |